Sin1 mediated
Webb4 okt. 2024 · Sin1 (stress-activated protein kinase-interacting protein) as an essential component of mTORC2 (mammalian target of rapamycin complex 2) is required for cell … Webb3 okt. 2024 · Particularly, knockdown SLC7A11 by siRNA showed that SLC7A11-mediated cystine uptake is responsible for activating mTORC2. Mechanistically, we found that p38 is activated in response to cystine stimulation, and co-immunoprecipitation experiments suggested that p38 regulated the assembly of components within mTORC2 by mediating …
Sin1 mediated
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Webb14 sep. 2024 · A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity. Sinem Yilmaz, Department of Biotechnology, Graduate School of Natural and Applied Sciences, Ege University, Izmir, Turkey. Webb27 okt. 2013 · Sin1 phosphorylation suppresses mTORC2 kinase activity towards phosphorylating Akt in vitro. (a,b) HEK293T cells were transfected with the indicated Flag-tagged Sin1 constructs. At 36 h...
Webb21 mars 2024 · This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding … Webb1 feb. 2024 · Sin1-mediated cell proliferation and invasion of PCa cells occurs by regulating mTORC2-AKT signaling, epithelial-mesenchymal transition and matrix metalloproteinases. Moreover, androgens are able...
WebbWe provide evidence that Sin1, a known element of the mammalian target of rapamycin complex 2 (mTORC2), is required for IFNγ-induced phosphorylation and activation of AKT and that such activation mediates downstream regulation of mTORC1 and its effectors. Webb19 nov. 2024 · S ty1/Spc1- in teracting protein 1 (Sin1), also known as mitogen-activated protein kinase ( MAPK) a ssociated p rotein (MAPKAP)1, was first identified in 1999 in fission yeast Schizosaccharomyces pombe as an adaptor protein interacting with Sty1 (also known as Spc1), a member of the eukaryotic stress-activated protein kinase …
Webb29 okt. 2024 · Therefore, Sin1 serves as the key component to mediate the cross talk between physiological signals and proper mTORC2 function. Although mTOR and Rictor …
Webb19 nov. 2024 · Sin1 mediates the crosstalk between mTORC1 and mTORC2. It is well appreciated that the main function of mTORC1 is sensing the intracellular nutrient levels, … list of global cities in the worldWebb19 nov. 2024 · Two distinct multi-protein mTOR complexes (mTORC), mTORC1 and mTORC2, have been identified and well characterized in eukaryotic cells from yeast to … list of global bankslist of glenn frey songsWebb6 okt. 2006 · (B) SIN1 is required for multiple growth factor-mediated Akt-Ser473 phosphorylation independent of nutrient input. Wild-type or SIN1 −/− MEFs were starved of serum and by nutrient (in PBS for the last 90 min) and then restimulated as indicated. p-Akt Ser473, p-Akt Thr308, total Akt, p-ERK1/2, and tubulin were determined by immunoblotting. ima in text messageWebb28 maj 2012 · See all SIN1 primary antibodies Description Rabbit polyclonal to SIN1 Host species Rabbit Tested applications Suitable for: WB, IP, IHC-P more details Species reactivity Reacts with: Human … list of global cities in the philippinesWebb17 okt. 2016 · Thus, localization at the plasma membrane is a key aspect of mTORC2 regulation. 9 An oncogenic mutation in the PH domain of mSin1 that blocks mSin1-mediated mTOR inhibition leading to... list of global city in the philippinesWebb14 nov. 2024 · Sin1 is one of the essential core components of mTORC2 and Sin1 deficiency leads to severely impaired phosphorylation of AKT at Ser473 and Thr450 … list of gliptin drugs