Cisplatin sensitivity

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August undefined, 2024

WebMay 1, 2005 · Analysis of A2780 cell sensitivity to cisplatin revealed a toxicity curve similar to that published previously ( 8) and a LD 50 of 3.0 μmol/L was calculated (data … WebJul 22, 2024 · Figure 1 Olaparib and cisplatin (CDDP) in vitro sensitivities are not influenced by the BRCA1 status of TNBC cells. (A) MTT assays of MDA-MB-468, SUM1315, MDA-MB-231 and HCC1937 cells. Data are mean ± S.D. of three independent experiments. (B) Isobologram analysis of the combination of olaparib and CDDP in constant 1:1 ratio.

Reversal of resistance to cisplatin in NSCLC by miRNA-195-5p

WebMay 17, 2012 · Cisplatin sensitivity correlated with the expression of 454 unique genes (P<0.01), corresponding to 68 pathways. Twenty-three of … WebApr 10, 2024 · Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10–20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance often hamper their clinical use. Hence, novel … fayette county circuit court clerk\u0027s office

How to cope with cold sensitivity during chemotherapy

WebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to … WebSo, we investigated the anti-cancer drug sensitivity in TMEPAI KO cells. Our results indicated that knock-out of TMEPAI significantly decreased IC 50 for doxorubicin and paclitaxel compared with WT parental cells. However, there are no significant changes in IC 50 for cisplatin and bicalutamide in WT and TMEPAI-KO cells . WebMar 25, 2024 · RRS1 silencing increased the sensitivity of MCF-7/DDP cells to cisplatin and inhibited cancer cell proliferation by blocking cell cycle distribution and enhancing apoptosis. AEG-1 (astrocyte elevated gene-1) promotes drug resistance by interfering with the ubiquitination and proteasomal degradation of MDR1 (multidrug resistance gene 1), … fayette county central court pa

Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin …

Cisplatin and the sensitive cell Nature Medicine

WebA recent study indicated that NKX2-1 may modulate cellular sensitivity to cisplatin by modulating the β-catenin pathway through phosphorylation of AKT . We here … WebMar 8, 2024 · XPV fibroblasts are sensitive to UV light and cisplatin but are corrected by transfection of POLHcDNA [1,13]. In this context, it is reasonable to postulate that human germline POLHvariants can alter the TLS activity and thus modify the susceptibility to toxic effects of UV and cisplatin in genetically affected individuals. fayette county case search gaWebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with ovarian cancer, a staggering 70% will become resistant to the front-line therapy, cisplatin. Although many mechanisms of cisplatin resistance have been proposed, the key mechanisms of … friendship bracelets with embroidery thread

"WebMay 14, 2024 · Cisplatin is a highly effective chemotherapy regimen for individuals with BCa. However, cisplatin-based chemotherapy would be effective in less than 50% of BCa patients (Sagalowsky 2013 ). Cell-cycle regulation is one of the major determinants of cisplatin chemosensitivity (Yang et al. 2024; Borst et al. 2014 ). " - Cisplatin sensitivity

Cisplatin sensitivity

Hypersensitivity Reactions Associated with Platinum Antineoplastic ...

WebSep 1, 2024 · The study established that cisplatin sensitivity is associated with changes in expression patterns of key players in cholesterol homeostasis. There is a reliance on cholesteryl ester availability... WebDetermining the factors that influence cellular sensitivity to cisplatin is thus important for understanding the anticancer activity of cisplatin and for developing a more effective platinum-based chemotherapy. The cytotoxicity of cisplatin arises from its ability to react with DNA and form covalent DNA adducts ( 4 ).

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WebNov 12, 2024 · Commonly reported side effects of cisplatin include: bone marrow depression, nephrotoxicity, and ototoxicity. Continue reading for a comprehensive list of … WebWorldwide, the number of cancer-related deaths continues to increase due to the ability of cancer cells to become chemotherapy-resistant and metastasize. For women with …

WebApr 1, 2024 · Abstract. NKX2-1 was shown to enhance cisplatin sensitivity in KRAS-mutated cells, but it conferred cisplatin resistance in EGFR-mutated lung adenocarcinoma … WebCarboplatin sIgE is very specific but less sensitive. In contrast, oxaliplatin sIgE had higher sensitivity but lower specificity. Analysis of our data suggests that oxaliplatin exposure …

WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. ... USP14 levels were higher in DDP-resistant lung cancer compared to DDP-sensitive lung ... WebNational Center for Biotechnology Information

WebSep 30, 2013 · In cisplatin-sensitive TC cell lines and the EC component of chemo-sensitive tumours, low levels of cytoplasmic p21 similarly correlated with high expression of Oct4 and of miRs belonging to the miR-17/106b seed family (Ref. Reference Koster40). P53 activity can be influenced by MDM2.

fayette county chamber of commerce facebookWeb2 days ago · Blockade of neddylation increases cisplatin sensitivity of testicular germ cell tumors. In turn, inhibition of the neddylation cascade leads to an accumulation of suppressor proteins and ... fayette county children and youth paWebThere is no relationship between the presence or severity of Cisplatin side effects and effectiveness of cisplatin. The following side effects are common(occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up … friendship bracelets with handsWebFeb 7, 2024 · The cytotoxicity of cisplatin was evaluated in six bladder cancer cell lines to compare their responses to cisplatin. The T24 cancer cells exhibited the lowest sensitivity to cisplatin and was therefore selected to explore the mechanisms of drug resistance. friendship bracelet string board directionWebJul 14, 2024 · Mechanismly, propofol enhances cisplatin sensitivity of NSCLC through miR-486-5p/RAP1-NF-κB axis. The finding provides a deeper understanding about the … fayette county christian schoolWebAug 1, 1996 · Purpose: Human glioma cell lines resistant (U373MGCP) and sensitive (U373MG) to cisplatin were used to evaluate the effect of cisplatin as a sensitizer to low dose rate irradiation (LDRI). Methods and materials: A cisplatin resistant glioma cell line U373MGCP was developed by chronic exposure of parental U373MG cells to cisplatin. . … friendship bracelets with namesWebDec 9, 2024 · By analysing RNA-seq data in OSCC cells treated with vitamin D and cisplatin, we found that lipocalin 2 (LCN2) was an important modulator of cisplatin … friendship bracelets with rubber bands