WebJul 29, 2024 · Introduction: Focal and Segmental GlomeruloSclerosis (FSGS) can cause nephrotic syndrome with a risk of progression to end-stage renal disease. The idiopathic form has a high rate of recurrence after transplantation, suggesting the presence of a systemic circulating factor that causes glomerular permeability and can be removed by … WebApr 1, 2013 · Another possible circulating factor is Cardiotrophin-like cytokine 1, however this candidate awaits further study . Animal models for FSGS. ... To date, there is no consensus on which candidate factor the actual “FSGS-factor” is or where it is produced. These studies support the existence of a circulating permeability factor, and have the ...
suPAR is the circulating factor in some but not all FSGS
WebThe initial study of suPAR in proteinuric kidney disease was largely prompted by the concept of a circulating blood factor that causes primary or recurrent focal segmental glomerulosclerosis (FSGS). FSGS refers to a histologic pattern that involves different etiology yet shares a common theme of podocyte injury and/or depletion . Generally ... WebIn primary FSGS, it is thought that podocyte injury may be related to a circulating permeability factor. The evidence for a circulating factor is supported by the high recurrence rate of FSGS after kidney transplant (within hours to weeks) . Serum urine-type plasminogen activator receptor (suPAR) has recently been identified as a potential ... how to filmora tracking object on video
Has the circulating permeability factor in primary FSGS been found ...
WebDec 1, 2012 · Circulating factor(s) in idiopathic FSGS and in post-transplant recurrence. Our studies of glomerular permeability using isolated glomeruli have permitted us to test the immediate effects of a number of substances that have been implicated as mediators of injury by studies of intact animals. The assay that we developed and have used in these ... WebOct 3, 2024 · Focal segmental glomerulosclerosis (FSGS), first described in 1957, is currently recognized as one of the most common causes of primary glomerular diseases in adults, and the incidence of FSGS has been increasing in recent years. ... Shankland SJ, Pollak MR. A suPAR circulating factor causes kidney disease. Nat Med. 2011 Aug 4. … WebUndefined circulating factor(s) that mediate abnormal glomerular permeability lead to segmental sclerosis in primary FSGS, with podocyte injury and dedifferentiation. Secondary FSGS can occur in other non–immune complex disease (eg, arterionephrosclerosis and reflux/chronic pyelonephritis nephropathy). how to filter a column in python